2-(Trimethylsilyl)ethoxymethyl chloride

Product Name: 2-(Trimethylsilyl)ethoxymethyl chloride
CAS No.: 76513-69-4
Chemical Name: 2-(Trimethylsilyl)ethoxymethyl chloride
Synonyms: SEM-CL;(2-trimethylethylsilylethoxy)methyl chloride;SEM-CI;2-(CHLOROMETHOXY)ETHYLTRIMETHYLSILANE;(Trimethylsilyl)ethoxymethyl chloride;DK891;2-(Trime;SEM-CHLORIDE;2-(triMethylsilyl)ethoxyMethyl chl;2-ChloroethoxyMethyltrimethylsilane
CBNumber: CB1275117
Molecular Formula: C6H15ClOSi
Formula Weight: 166.72
MOL File: 76513-69-4.mol

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2-(Trimethylsilyl)ethoxymethyl chloride Property

Boiling point:: 170-172 °C (lit.) 57-59 °C/8 mmHg (lit.)
Density: 0.942 g/mL at 25 °C (lit.)
refractive index: n20/D 1.435(lit.)
Flash point:: 116 °F
storage temp.: 2-8°C
solubility: Sol most organic solvents (pentane, CH2Cl2, Et2O, THF, DMF, DMPU, HMPA)
form: Liquid
color: Clear colorless
Specific Gravity: 0.95
Water Solubility: decomposes
Sensitive: Moisture Sensitive
Hydrolytic Sensitivity: 7: reacts slowly with moisture/water
BRN: 3587289
Stability:: Unstable in Solution
InChIKey: BPXKZEMBEZGUAH-UHFFFAOYSA-N
CAS DataBase Reference: 76513-69-4(CAS DataBase Reference)

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Safety

Hazard Codes: C
Risk Statements: 10-34
Safety Statements: 26-28-36/37/39-45-16
RIDADR: UN 2920 8/PG 2
WGK Germany: 3
F: 8-10-21
TSCA: No
HazardClass: 3.2
PackingGroup: III
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 238902
Product name: 2-(Trimethylsilyl)ethoxymethyl chloride
Purity: technical grade
Packaging: 1g
Price: $57.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: 238902
Product name: 2-(Trimethylsilyl)ethoxymethyl chloride
Purity: technical grade
Packaging: 5g
Price: $154
Updated: 2024/03/01

TCI Chemical

Product number: C1339
Product name: 2-(Chloromethoxy)ethyltrimethylsilane (stabilized with Diisopropylethylamine)
Purity: >95.0%(GC)
Packaging: 5mL
Price: $134
Updated: 2024/03/01

TCI Chemical

Product number: C1339
Product name: 2-(Chloromethoxy)ethyltrimethylsilane (stabilized with Diisopropylethylamine)
Purity: >95.0%(GC)
Packaging: 25mL
Price: $457
Updated: 2024/03/01

Alfa Aesar

Product number: H55074
Product name: 2-(Chloromethoxy)ethyltrimethylsilane, tech. 90%, stab. with 0.1% N,N-Diisopropylethylamine
Packaging: 1g
Price: $36.65
Updated: 2024/03/01

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2-(Trimethylsilyl)ethoxymethyl chloride Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liqui

Physical properties

bp 57–59 °C/8 mmHg; d 0.942 g cm?3.

Uses

2-(Chloromethoxy)ethyltrimethylsilane is used in the preparation of SEM [2-(trimethylsilyl)ethoxy]methyl]-ethers. It serves as a phenol protecting group in the synthesis of laterifluorones. Further, it reacts with 1H-imidazole to prepare 1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole.

Uses

2-(Trimethylsilyl)ethoxymethyl Chloride is a reagent used in the protection of alcohols, secondary aryl amines, and imidazole, indole, and pyrrole nitrogens;electrophilic formaldehyde equivalent; acyl anion equivalent,used in One-carbon Homologations, Cyclizations etc.

General Description

2-(Trimethylsilyl)ethoxymethyl chloride (SEM-Cl) is a widely used reagent for the preparation protection groups for amines, alcohols, phenols, and carboxy groups. The nitrogen of amides and sulfonamides groups are also protected by using SEM-Cl reagent.

Purification Methods

Dissolve SEMCl in pentane, dry it (MgSO4), evaporate and distil the residual oil in a vacuum. Stabilise it with 10ppm of diisopropylamine. Store it under N2 in a sealed container in a refrigerator. [Lipshutz & Pegram Tetrahedron Lett 21 3343 1980.]

2-(Trimethylsilyl)ethoxymethyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(Trimethylsilyl)ethoxymethyl chloride Suppliers

Americas 1 Belgium 2 China 312 Europe 1 France 2 Germany 4 India 14 Japan 3 Singapore 1 South Korea 1 Switzerland 2 United Kingdom 14 United States 40 Global 397

HBCChem, Inc.

Tel: +1-510-219-6317
Fax: +1-650-486-1361
Email: sales@hbcchem.com
Country: United States
ProdList: 10658
Advantage: 60

Alfa Chemistry

Tel: 1-516-6625404
Fax: 1-516-927-0118
Email: support@alfa-chemistry.com
Country: United States
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Advantage: 60

Alfa Chemistry

Tel: +1-5166625404
Fax: 1-516-927-0118
Email: Info@alfa-chemistry.com
Country: United States
ProdList: 21317
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
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Aladdin Scientific

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Email: sales@aladdinsci.com
Country: United States
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Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

Aceschem Inc.

Tel: +1-817863-6948 +1-（817）863-6948
Email: sales@aceschem.com
Country: United States
ProdList: 19639
Advantage: 58

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View Lastest Price from 2-(Trimethylsilyl)ethoxymethyl chloride manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: 2-(Trimethylsilyl)ethoxymethyl chloride 76513-69-4
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99.10%
Supply Ability: 50000kg
Release date: 2024-04-28

Hebei Xinsheng New Material Technology Co., LTD.

Product: 2-(Trimethylsilyl)ethoxymethyl chloride 76513-69-4
Price: US $35.00-25.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 Ton
Release date: 2023-11-16

Hangzhou ICH Biofarm Co., Ltd

Product: 2-trimethylsilyl) thoxymethyl chloride 76513-69-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99.0%
Supply Ability: 20 tons
Release date: 2023-07-03

76513-69-4, 2-(Trimethylsilyl)ethoxymethyl chlorideRelated Search:

(Trifluoromethyl)trimethylsilane Choline chloride Chlorodimethylphenylsilane Chloromethyltrimethylsilane Ethoxytrimethylsilane Ethyl acetate Ammonium chloride C8E3 Lithium bis(trimethylsilyl)amide Methyltrimethoxysilane Diethoxydimethylsilane tert-Butyldimethylsilyl chloride Ethylbenzene Polyvinyl chloride Acetyl chloride Trimethylsilylacetylene Sodium chloride CHLOROMETHYLPHENYLSILANE

SEM-CHLORIDE

SEM-CI

SEM-CL

2-(TRIMETHYLSILYL)ETHOXYMETHYL CHLORIDE

2-(CHLOROMETHOXY)ETHYLTRIMETHYLSILANE

CHLOROMETHYL 2-TRIMETHYLSILYLETHYL ETHER

2-(Trimethylsilyl)ethoxymethyl chloride ,95% [0.1% diisopropylethylamine as stabilizer]

2-(triMethylsilyl)ethoxyMethyl chl

2-(ChloroMethoxy)ethyltriMethylsilane, tech.

SEM-Chloride 2-(Trimethylsilyl)ethoxymethyl Chloride

SEM-Cl 2-(TriMethylsilyl)ethoxyMethyl chloride

2-(ChloroMethoxy)ethyltriMethylsilane, tech. 90%, stab. with 0.3% N-ethyldiisopropylaMine

2-(TriMethsilyl)-ethoxyMethyl chloride

2-(TriMethylsilyl)ethoxyMethyl Chloride, Stabilized with N,N-Dicyclohexyl-3-pentylaMine

2-(TriMethylsilyl)ethoxyMethyl chloride, stabilized with 10 ppM N,N-diisopropylethylaMine

2-(TriMethylsilyl)ethoxyMethyl chloride >=95.0% (GC)

2-(Chloromethoxy)ethyltrimethylsilane, stabilized with 0.3% N-ethyldiisopropylamine

2-(Chloromethoxy)ethyltrimethylsilane, tech. 90%, stab. with 0.3% N-ethyldiisopropylamine colorless liquid

2-(Trimethylsilyl)ethoxymethyl chloride, 95%, stabilized with 10 ppm N,N-diisopropylethylamine

2-(Trime

(Trimethylsilyl)ethoxymethyl chloride

2-(Chloromethoxyethyl)trimethyl silane - stabilized with ca. 0.1% Diisopropylethylamine

2-chloromethyl 2-(trimethylsilyl)ethyl ether

2-(Trimethylsilyl)ethoxymethyl chloride, technical grade

2-(TRIMETHYSILYL)-ETHOXYMETHYL CHLORIDE

2-(Trimethylsilyl)ethoxymethylchloride,stabilized,tech.

2-(Trimethylsilyl)ethoxymethyl chloride, tech., stabilized, 90%

2-(Trimethylsilyl)ethoxymethyl Chloride (SEM-Cl)

2-ChloroethoxyMethyltrimethylsilane

-(trimethysilyl)-ethoxymethylchloride

Silane, 2-(chloromethoxy)ethyltrimethyl-

{2-[(chloromethyl)oxy]ethyl}(trimethyl)silane

2-(Chloromethoxy)ethyltrimethylsilane (stabilized with Diisopropylethylamine)

2-(Trimethylsilyl)ethoxymethyl chloride, 90%, tech, stabilized

[2-(Trimethylsilyl)ethyl](chloromethyl) ether

2-(Trimethylsilyl)ethyl(chloromethyl) ether

2-(TRIMETHYLSILYL)ETHOXYMETHYLCHLORIDE , STABILIZED WITH IPR2MEN

(2-Chloromethoxyethyl)trimethylsilane, Chloromethyl 2-trimethylsilylethyl ether, SEM-chloride, SEM-Cl

2-(Chloromethoxy)ethyltrimethylsilane (stabilized with Diisopropylethylamine)&gt

2-(Trimethylsilyl)ethoxymethyl Chloride，>95%

(2-trimethylethylsilylethoxy)methyl chloride

2-chloroMethyl 2-(triMethylsilyl)ethyl ethe

4,4'-METHYLENEBIS(7-BROMO-N,N-DIMETHYLANILINE)

DK891

SEM-CHLORIDE ~9% (2-(Trimethylsilyl)ethoxymethyl chloride)

Chloromethyl trimethylsilethyl ether

2-trimethylsilyl) thoxymethyl chloride

2-(TRIMETHYLSILYL)ETHOXYMETHYL CHLORIDE (2-Chloromethoxyethyl)trimethylsilane, Chloromethyl 2-trimethylsilylethyl ether, SEM-Cl, SEM-chloride

76513-69-4

76512-69-4

C6H15ClOSi

CH33SiCH2CH2OCH2Cl

Si (Classes of Silicon Compounds)

Protection & Derivatization Reagents (for Synthesis)

Si-(C)4 Compounds

Reagents for Oligosaccharide Synthesis

Silicon Compounds (for Synthesis)

Protecting and Derivatizing Reagents